L - Methyl Folate


  • 5-Methyltetrahydrofolic acid is a biologically active form of folic acid that functions, in conjunction with vitamin B12, as a methyl-group donor involved in the conversion of homocysteine to methionine.
  • The availability of methyl groups is essential for a variety of methylation reactions including the synthesis of DNA and proper neural tube closure.
  • It has been used to restore nitric oxide-generating activity in cases of familial hypercholesterolemia or hyperhomocysteinemia, reducing homocysteine levels and improving vascular endothelial function.

QUALITY STANDARD: 99.9% purity by HPLC


  • L-5-Methyltetrahydrofolate Calcium is a synthetic derivative of folic acid, the predominant, naturally occurring form of folate. It is the nutritionally active form.
  • When folic acid is absorbed into the body, it must undergo several metabolic steps before converting to L-methylfolate, the active form of folate in the blood and the only type that can cross the blood-brain barrier.


  • It is the only form of folate that appears normally in the plasma and is internalized by cells for use.
  • 7 times more bio available than folic acid.
  • As because of higher bioavailability, it is more economical and highly efficient.
  • Able to cross the “blood-brain” barrier to aid in the synthesis of neurotransmitters and other neurological benefits, unlike folic acid.
  • Reduces toxic levels of homocysteine significantly greater than folic acid.
  • Increases RBC folate better than folic acid.